For typical Illumina 100bp reads or longer low-divergence query sequences, BWA-MEM is about twice as fast sex Süchtige Telefon treffen as BWA and BWA-SW and is more accurate.
Part of the ALT mapping strategy is implemented in BWA-MEM and the rest in a postprocessing script for now.
It is more accurate for highly unique reads and more robust to long indels and structural variations.
Take name-grouped BAM files as input.In addition, there is an example of running bwa aln with single-end input_reads.BWA-MEM generally gives better pre-filtered SNP calls than BWA.Last is still a little more sensitive on older bacterial data, but bwa-mem is as good on more recent data and is times faster for mapping against mammalian genomes.Fixed a bug in generate SAM.Although older BWA-MEM works with PacBio data in principle, the resultant alignments are frequently fragmented.Further improvement is a little difficult and may affect the code stability.(0.4.1:, r760) Beta Release.4.0 (6 January, 2009) In comparison to the release two days ago, this release is mainly tuned for performance with some tricks I learnt from Bowtie.However, as BWA-MEM is usually better, I will not improve BWA-SW until I find applications where BWA-SW may excel.Old bwa-mem waits for I/O.Support PacBio subread-to-subread alignment (experimental).Insufficient band width leads to wrong cigar sex sucht internet and spurious mismatches/indels.Automatically choose the maximum allowed number of differences.Bugfix: wrong cigar when a query sequence bridges three or more target sequences.This includes a change to scoring based on a study done by Aaron Quinlan and a heuristic speedup.Other notable changes in BWA are: Fixed a rare bug in the Smith-Waterman alignment module.Color errors are corrected in this process.It may occur when mapping is much faster than file reading, which should almost never happen in practice.